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Resistance to avian influenza in chickens

10/03/2025

Genetic resistance studies in poultry have shed light on avian influenza. The ANP32A gene in the chicken genome plays a key role in the development of resistant breeds.

The global agriculture and livestock sector has been facing the threat of avian influenza more frequently in recent years. This deadly virus, which affects poultry, causes production losses and economic losses worldwide. However, scientists are demonstrating the power of genetics in the hope of developing natural resistance in chickens. According to research, certain genetic characteristics can enable chickens to develop resistance to this disease.

The story of genetic research

In 2015, during the highly pathogenic avian influenza (HPAI) outbreak, a group of chickens managed to survive despite a 99% mortality rate. The genetic structures of these animals astonished scientists.

Gene editing in chickens holds promise for both healthy production and sustainable agriculture.

In research conducted at the Roslin Institute in England, blood samples taken from these chickens were examined. 9 different genetic regions associated with the immune system and resistance to the virus were discovered in the chickens' DNA.

It was understood that one of these regions, the ANP32A gene, was particularly striking. This gene plays a key role in the reproduction of influenza viruses. By examining the genetic structure, it was revealed that some variations of this gene can limit the effect of the virus. The studies on ANP32A are not limited to avian influenza, but may also provide important clues for other types of flu. Researchers collaborating with the Roslin Institute are investigating how gene editing technologies can be used to combat avian influenza. The CRISPR-Cas9 technology aims to make chickens resistant to the virus by making precise edits to their genetic code. The first results are promising: chickens genetically edited in the laboratory have become more resistant to avian influenza.

These studies are not only critical for protecting the health of the animals, but also for securing the global food supply. Genetic editing can prevent chickens from becoming carriers of avian influenza and significantly slow the spread of the virus.

Sustainability and ethical debates

The ethical and biosafety questions raised by genetic interventions are among the issues that need to be carefully addressed for the future of such projects. Preserving genetic diversity is essential for a sustainable poultry industry. In addition, more research is needed on the environmental impacts of genetically modified animals and their potential consequences on public health.

Scientists emphasize that these genetic interventions are a tool not only to increase production, but also to improve animal welfare and minimize environmental impacts. Genetic interventions aim to reduce drug use, healthier animals and lower environmental costs.

The importance of vaccine development studies

Genetic research is not limited to the development of resistant chickens. Studies conducted at the Pirbright Institute show that genetic engineering can allow the development of more effective vaccines. For example, data obtained from genetically modified chickens has paved the way for the development of more powerful vaccines against other viral infections such as Marek's disease. It is stated that this technology can also be used against diseases such as avian influenza.

Future prospects against avian influenza

Studies on developing genetic resistance to avian influenza continue to be a promising area for the poultry industry. Scientists believe that genetic technologies can usher in a new era in the fight against the virus. The development of more resistant chicken breeds will not only reduce economic losses, but also strengthen global food security.

In order for technological advances in this field to be successful, scientific innovations must be carefully evaluated. It should not be forgotten that genetic science can be used not only to raise healthier animals, but also to create an environmentally friendly and sustainable production model.

In conclusion, studies on developing genetic resistance to avian influenza in chickens reveal how scientific discoveries and technological innovations can revolutionize the agricultural sector. Such studies seem to shape not only the livestock sector, but also the future food security perspective of humanity.

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